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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-1
All Species:
9.09
Human Site:
S233
Identified Species:
20
UniProt:
P43699
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43699
NP_001073136.1
371
38596
S233
Q
Q
Q
L
Q
Q
D
S
G
G
G
G
G
G
G
Chimpanzee
Pan troglodytes
XP_509911
401
41649
S263
Q
Q
Q
L
Q
Q
D
S
G
G
G
G
G
G
G
Rhesus Macaque
Macaca mulatta
XP_001089890
371
38509
S233
Q
Q
Q
L
Q
Q
D
S
G
G
G
G
G
G
G
Dog
Lupus familis
XP_849082
233
24205
R117
K
I
W
F
Q
N
H
R
Y
K
M
K
R
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
P50220
372
38552
G234
Q
Q
L
Q
Q
D
S
G
G
G
G
G
G
G
G
Rat
Rattus norvegicus
P23441
372
38536
G234
Q
Q
L
Q
Q
D
S
G
G
G
G
G
G
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
R178
R
Y
K
C
K
R
Q
R
Q
D
Q
T
L
E
M
Frog
Xenopus laevis
P42587
196
22791
Q80
R
V
L
F
S
K
A
Q
T
Y
E
L
E
R
R
Zebra Danio
Brachydanio rerio
Q90481
269
30288
P153
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
L183
T
A
P
E
R
E
Q
L
A
N
S
I
R
L
T
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
V283
D
R
S
L
S
G
Q
V
E
G
V
S
D
Q
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.7
99.1
40.7
N.A.
98.1
98.6
N.A.
N.A.
32
30.7
32.6
N.A.
N.A.
N.A.
26.6
38.4
Protein Similarity:
100
91.7
99.1
46.6
N.A.
98.1
98.6
N.A.
N.A.
43.4
40.4
43.4
N.A.
N.A.
N.A.
40.4
50.3
P-Site Identity:
100
100
100
6.6
N.A.
66.6
66.6
N.A.
N.A.
0
0
13.3
N.A.
N.A.
N.A.
0
20
P-Site Similarity:
100
100
100
13.3
N.A.
66.6
66.6
N.A.
N.A.
26.6
13.3
20
N.A.
N.A.
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
19
0
10
0
0
0
0
10
10
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
19
28
0
0
10
0
0
10
0
0
% D
% Glu:
0
0
0
10
0
10
0
0
19
0
19
0
10
10
0
% E
% Phe:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
19
46
55
46
46
46
46
55
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
10
0
10
0
10
10
0
0
0
10
0
10
0
0
0
% K
% Leu:
0
0
28
37
10
0
0
10
0
0
0
10
19
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% M
% Asn:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% P
% Gln:
55
55
28
19
55
28
28
10
10
0
10
0
0
19
0
% Q
% Arg:
19
10
10
0
10
10
0
19
0
10
0
0
19
10
10
% R
% Ser:
0
0
10
0
19
10
19
28
0
0
10
10
0
0
10
% S
% Thr:
10
0
0
0
0
0
0
0
10
0
0
10
0
0
10
% T
% Val:
0
10
0
0
0
0
0
10
0
0
10
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
10
0
0
0
0
10
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _